How ZEJULA (niraparib) Works
ZEJULA is a type of treatment known as a PARP inhibitor
PARP, or poly (ADP-ribose) polymerase, is a protein that helps repair damaged DNA in both healthy cells and cancer cells.
PARP inhibitors work to stop PARP from repairing cancer cells.
This may lead to cancer cell death, and slow the return or progression of cancer. PARP inhibitors can also impact other cells and tissues in the body.
The goal of maintenance therapy with PARP inhibitors is to delay recurrence. All PARP inhibitors are taken orally, which gives you the flexibility to take them at home, although routine monitoring may be required.
How does ZEJULA work?
PARP is a protein that helps repair DNA damage in cells
PARP helps healthy cells keep working normally. Cancer cells also use PARP to help repair DNA damage. This helps cancer cells survive and spread.
ZEJULA helps stop PARP from repairing cancer cells
Without PARP, cancer cells can’t repair certain kinds of DNA damage. Since all cells also use PARP, ZEJULA may also affect healthy cells.
Blocking PARP can help kill cancer cells
Over time, DNA damage can build up in cancer cells and cause them to die.