Understanding Maintenance Therapy

Not sure what maintenance therapy is and what's involved with it? Start here.

Maintenance therapy and ovarian cancer recurrence

Even if treatment with chemotherapy is successful, many ovarian cancer patients may still see their cancer come back. This is called recurrence, and it can happen even when it seems like you’re in remission. It's difficult to think about the possibility of ovarian cancer returning, but today, there are options that can help you take action to help delay it. As you discuss any future treatment plans with your doctor, it is important to know your options, one of which is maintenance therapy.

‌Get to know the basics

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What

is maintenance therapy?

Maintenance therapy is a treatment given after completing chemotherapy to help extend the time before cancer returns.

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When

should I start talking about maintenance therapy with my healthcare team?

You can talk with your healthcare team before, during, or toward the end of chemotherapy to see if starting maintenance therapy after you respond to chemotherapy is right for you.

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Why

do patients choose maintenance therapy?


While each patient has their own reasons, maintenance therapy may be an active step you can take in your ovarian cancer care plan.

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Where

does maintenance therapy fit in a treatment plan?

 

Talking to your healthcare team will give you an idea of where and when maintenance therapy may fit into your individualized treatment plan.

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Could ZEJULA maintenance therapy be your “what’s next”?

ZEJULA is approved as a maintenance treatment for:

 

  • Newly diagnosed advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who responded completely or partially to platinum-based chemotherapy.

  • Recurrent germline BRCA-mutated (gBRCAm) ovarian cancer, fallopian tube cancer that comes back, or primary peritoneal cancer that comes back, who responded completely or partially to platinum-based chemotherapy. Your doctor will perform a test to see if you have the BRCA gene.

Want more info about maintenance therapy with ZEJULA?

Sign up to receive a free ZEJULA information kit

Not taking ZEJULA yet? Get a kit filled with resources that help you learn more about ZEJULA.

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Discover how ZEJULA, a PARP inhibitor, works

The first thing to know is ZEJULA is a PARP inhibitor.

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Focus on yourself

On the good days and the not-so-great, remember to take some time for self-care.

Approved Uses & Safety Info

Approved Uses

ZEJULA is a prescription medicine used for the:

  • maintenance treatment of adults with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. ZEJULA is used after the cancer has responded (complete or partial response) to treatment with platinum-based chemotherapy.
  • maintenance treatment of adults with a certain type of inherited (germline) abnormal BRCA gene with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that comes back. ZEJULA is used after the cancer has responded (complete or partial response) to treatment with platinum-based chemotherapy. Your healthcare provider will perform a test to make sure that ZEJULA is right for you.  

 

It is not known if ZEJULA is safe and effective in children.

Important Safety Information

ZEJULA may cause serious side effects, including:

 

Bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of blood cancer called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during treatment with ZEJULA. MDS or AML may lead to death.

 

Symptoms of low blood cell counts (low red blood cells, low white blood cells, and low platelets) are common during treatment with ZEJULA. They can be a sign of serious bone marrow problems, including MDS or AML. These symptoms may include the following:

  • Weakness
  • Feeling tired
  • Weight loss
  • Frequent infections
  • Fever
  • Shortness of breath
  • Blood in urine or stool
  • Bruising or bleeding more easily


Your doctor will do blood tests to check your blood cell counts before treatment with ZEJULA. You will be tested weekly for the first month of treatment with ZEJULA, monthly for the next 11 months of treatment, and as needed afterward.

 

High blood pressure is common during treatment with ZEJULA, and it can become serious. Your doctor will check your blood pressure and heart rate at least weekly for the first two months, then monthly for the first year, and as needed thereafter during your treatment with ZEJULA.

 

Posterior reversible encephalopathy syndrome (PRES) is a condition that affects the brain and may happen during treatment with ZEJULA. If you have headache, vision changes, confusion, or seizure, with or without high blood pressure, please contact your doctor.

 

Before starting to take ZEJULA, tell your doctor about all of your medical conditions, including if you:

  • Have heart problems
  • Have liver problems
  • Have high blood pressure
  • Are pregnant or plan to become pregnant. ZEJULA can harm your unborn baby and may cause loss of pregnancy (miscarriage)
    • If you are able to become pregnant, your doctor should perform a pregnancy test before you start treatment with ZEJULA
    • If you are able to become pregnant, you should use effective birth control (contraception) during treatment with ZEJULA and for 6 months after taking the last dose of ZEJULA
    • You should tell your doctor right away if you become pregnant
  • Are breastfeeding or plan to breastfeed
    • ZEJULA may harm your baby. You should not breastfeed your baby during treatment with ZEJULA and for 1 month after taking the last dose of ZEJULA


Tell your doctor about all the medicines you take,
 including prescription and over-the-counter medicines, vitamins, and herbal supplements.

 

The most common side effects of ZEJULA include the following:

  • Nausea
  • Tiredness
  • Constipation
  • Pain in your muscles and back
  • Pain in the stomach area
  • Vomiting
  • Loss of appetite
  • Trouble sleeping
  • Headache
  • Shortness of breath
  • Rash
  • Diarrhea
  • Cough
  • Dizziness
  • Changes in the amount or color of your urine
  • Urinary tract infection
  • Low levels of magnesium in the blood


If you have certain side effects, then your doctor may change your dose of ZEJULA, temporarily stop, or permanently stop treatment with ZEJULA.

 

These are not all the possible side effects of ZEJULA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

 

Please see accompanying full Prescribing Information for ZEJULA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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Explore the GSK Help Center website to find customer service support and contact information.

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If you have questions about how to access your GSK medication or need cost information, visit gskforyou.com or call 1-866-GSK-FOR-U (1-866-475-3678).